Longitudinal study of Alzheimer’s Disease (AD) risk and resilience factors in the Human Connectome Project (HCP) in Aging Cohort

Status: In progress
Washington University PI: Beau Ances
University of Ljubljana PI: Grega Repovš
Duration: 30.9.2021 - 31.8.2026

Overview

The project follows the efforts of the Human Connectome Project (HCP) in advancing data acquisition, analysis, and data sharing that enabled the success of the original Young Adult HCP (HCP-YA), the subsequent HCP Development and Aging (HCP-D and HCP-A) projects, and the Connectomes Related to Human Disease (CRHD) projects. The project will provide informatics and data analysis services to support cross-sectional and longitudinal processing of collected data. Specific aims of the project are to (i) archive, preprocess, analyse and share imaging data through the NIH’s NIMH Data Archive (NDA), (ii) develop and maintain preprocessing and analysis pipelines, including longitudinal pipelines, to produce multi-modal imaging data phenotypes for all projects, (iii) perform quality control on imaging data and analysis results, and (iv) develop and analyze project statistical models driven by project specific hypotheses.

MBLab has joined the project as a project consortium member to support the development of neuroimaging analysis tools and their integration in the QuNex toolbox.